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<span style="vertical-align: inherit;">&bull; XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous</span>

<span style="vertical-align: inherit;">system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression),</span>

<span style="vertical-align: inherit;">coma, and death.</span>

<span style="vertical-align: inherit;">Get emergency help right away if any of the following happens:</span>

<span style="vertical-align: inherit;">&bull; Shallowed or slowed breathing.</span>

<span style="vertical-align: inherit;">&bull; Breathing stops (which may lead to the heart stopping)</span>

<span style="vertical-align: inherit;">&bull; Excessive sleepiness (sedation)</span>

<span style="vertical-align: inherit;">Do not drive or operate heavy machinery until you know how taking XANAX with opioids affects you.</span>

<span style="vertical-align: inherit;">&bull; There is a risk of abuse, misuse, and addiction with XANAX, which can lead to overdose and serious side effects, including</span>

<span style="vertical-align: inherit;">coma and death, delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. You can develop an addiction</span>

<span style="vertical-align: inherit;">even if you take XANAX as prescribed by your healthcare provider.</span>

<span style="vertical-align: inherit;">&bull; XANAX can cause physical dependence and withdrawal reactions. Do not suddenly stop taking XANAX as it may lead to</span>

<span style="vertical-align: inherit;">serious and life-threatening side effects, including unusual movements, responses, or expressions, seizures, sudden and severe</span>

<span style="vertical-align: inherit;">mental or nervous system changes, depression, seeing or hearing things that others do not, an extreme increase in activity or talking,</span>

<span style="vertical-align: inherit;">losing touch with reality, and suicidal thoughts or actions.</span>

<span style="vertical-align: inherit;">CALL YOUR HEALTHCARE PROVIDER OR GO TO THE HOSPITAL EMERGENCY ROOM RIGHT AWAY IF YOU GET ANY OF THE ABOVE</span>

<span style="vertical-align: inherit;">LIFE-THREATENING OR SERIOUS SIDE EFFECTS.</span>

<span style="vertical-align: inherit;">XANAX is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep XANAX in a safe place to</span>

<span style="vertical-align: inherit;">prevent misuse and abuse. It is not known if XANAX is safe and effective in children.</span>

<span style="vertical-align: inherit;">Do not take XANAX if you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX. Do not take XANAX if</span>

<span style="vertical-align: inherit;">you are taking antifungal treatments, including ketoconazole or itraconazole.</span>

<span style="vertical-align: inherit;">Before you take XANAX, tell your healthcare provider about all your medical conditions, including if you:</span>

<span style="vertical-align: inherit;">&bull; Have or have had depression, mood problems, or suicidal thoughts or behavior.</span>

<span style="vertical-align: inherit;">&bull; Have liver or kidney problems.</span>

<span style="vertical-align: inherit;">&bull; Have lung disease or breathing problems.</span>

<span style="vertical-align: inherit;">XANAX is indicated to treat anxiety disorders and for the short-term relief of symptoms of anxiety. XANAX is also indicated to treat panic disorder with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).</span>

<span style="vertical-align: inherit;">IMPORTANT SAFETY INFORMATION AND INDICATIONS</span>

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<span style="vertical-align: inherit;">What is the most important information I should know about XANAX?</span>



<span style="vertical-align: inherit;">XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death.</span>

<span style="vertical-align: inherit;">Get emergency help right away if any of the following happens:</span>

<span style="vertical-align: inherit;">&bull; XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous</span>

<span style="vertical-align: inherit;">system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression),</span>

<span style="vertical-align: inherit;">coma, and death.</span>

<span style="vertical-align: inherit;">Get emergency help right away if any of the following happens:</span>

<span style="vertical-align: inherit;">&bull; Shallowed or slowed breathing.</span>

<span style="vertical-align: inherit;">&bull; Breathing stops (which may lead to the heart stopping)</span>

<span style="vertical-align: inherit;">&bull; Excessive sleepiness (sedation)</span>